Created: 18 September 2007 | Watched by: 9 people | Comments: 0 comments

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  High throughput cell nanomechanics with mechanical imaging interferometry 

  http://www.iop.org/EJ/abstract/0957-4484/19/23/235101

  Abstract. The dynamic nanomechanical properties of a large number of cells (up to hundreds), measured in parallel with high throughput, are reported. Using NIH 3T3 and HEK 293T fibroblasts and actin depolymerizing ... drugs, we use a novel nanotechnology to quantify the local viscoelastic properties with applied forces of 20 pN–20 nN, a spatial resolution of <20 nm, and a mechanical dynamic range of several Pa up to ~200 kPa. Our approach utilizes imaging interferometry in combination with reflective, magnetic probes attached to cells. These results indicate that mechanical imaging interferometry is a sensitive and scalable technology for measuring the nanomechanical properties of large arrays of live cells in fluid. Print publication: Issue 23 (11 June 2008) Received 3 December 2007, in final form 7 February 2008 Published 6 May 2008   [More...] [Less...]

  First added: 11 July 2008, by: James Gimzewski  [Report as spam]

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  Tags:  nanomechanics, cell, iet, inspec, articles , free, interferometry, nanotechnology   [More...] [Less...]